News : 2011 : November

New Brain Vaccine Aims to Turn Fatal Disease into Chronic

The Miami Herald
by Fred Tasker

The University of Miami and nine other institutions are in trials for a new cancer vaccine they hope will change usually fatal brain tumors into manageable diseases patients can live with.

When U.S. Sen. Edward Kennedy was diagnosed with a glioblastoma of the brain in May 2009, doctors understood there was little chance he could survive it. He died that August.

“That’s a malignant tumor. The current five-year survival rate is 1 percent,” says Ricardo Komotar, a neurooncologist at Sylvester Comprehensive Cancer Center.

But cancer specialists from the University of Miami Medical School and nine other U.S. institutions are well into clinical experiments aimed at ending the tumor’s fatal reputation.

“We’re not going to cure it,” says Komotar, who is also director of surgical neurooncology at UM Hospital. “Our goal is to convert it into a chronic condition like high blood pressure or diabetes that you can live the rest of your life with and live a very normal life.”

Their weapon: a brain cancer vaccine. It’s not a preventive vaccine like a flu or polio shot, given to ward off disease. Instead, it’s a “therapeutic” vaccine given after the patient already has the tumor. It’s still called a vaccine because, unlike most cancer medicines, it doesn’t attack the disease directly. Instead, it marshals the body’s own immune system to attack it.

“This is the future of cancer therapy,” Komotar says. “Radiation and chemotherapy fight the cancer but they also kill normal cells, and they’re toxic. This kills the cancer without harming normal tissue.”

Sheryl Shetsky, president of the Florida Brain Tumor Association, said the research is important because “glioblastomas are 30 percent of all brain tumors, and they’re the most devastating tumor. You’re still going to want radiation and chemo for others cells you can’t see. But this can buy the patient a lot more time.”

The new vaccine is given quickly after a patient’s glioblastoma is diagnosed, Komotar says —before surgery, chemotherapy or radiation — because doctors need to use the excised tumor to make the vaccine.